Ionis Pharmaceuticals, Inc. IONS

Healthcare · Biotechnology · valued as of 2026-11-03 · statements 2025-12-31

Average Intrinsic Value
$440.18M
Market Cap
$7.32B
Margin of Safety
-1562.8%
Intrinsic / Market Ratio
0.06

How Each Value Is Built

The screener's three formulas on the reported figures. Each card reads the same way: the value as a sum of numbered terms, each term's calculation opened under it, from the reported figures to the value. The list ranks companies by their plain average over the market cap.

EPV + Growth

440.18M USD

what the normal year's earnings are worth for ever, plus growth that pays

Profit

440.18M USD

15 years of cash the shareholders can take out, and the equity left at year 15

FCFF

440.18M USD

15 years of cash for shareholders and lenders, less what is owed

Intrinsic Value

440.18M USD

the plain average of the three, uncapped, as the screener averages them

Intrinsic Value

440.18M USD

from the sum above

Market Cap

7.32B USD

today's price times the shares

Intrinsic Value ÷ Market Cap

0.06×

the ratio the screener ranks by; Margin of Safety -1562.8% (1 − Market Cap ÷ Intrinsic Value)

Each card below builds one of the three values from the reported years.

Earnings power value plus growth: 440.18M USD
What the normal year's operating profit after tax is worth if it lasts for ever, plus what the new investment adds beyond its cost, less the net debt that comes before the shareholders (or plus the net cash).

The earnings power value was not computed (a NOPAT at or below zero this year), so the value is the book value today, 440.18M USD.

Market value

Market Cap7.32B USD

Today's price times the shares.

Value vs market

Margin of Safety-1562.8%

1 minus the market cap as a share of the value.

Profit value: today's value of the shareholders' equity, from the cash it can pay them (FCFE): 440.18M USD
Fifteen years of free cash flow to equity (FCFE), each brought to today at the cost of equity, plus the equity at year 15 brought to today.

The projection was not made (a profit at or below zero in the latest three years), so the value is the book value today, 440.18M USD, as the screener leaves it.

①Present Value of the 15 Years of FCFE

Not in the value

②Equity at Year 15, Today

Not in the value

Market value

Market Cap7.32B USD

Today's price times the shares.

Value vs market

Margin of Safety-1562.8%

1 minus the market cap as a share of the value.

FCFF value: today's value of the shareholders' equity, from the cash the firm can pay its shareholders and lenders (FCFF): 440.18M USD
Fifteen years of free cash flow to the firm (FCFF), each brought to today at the WACC, plus the invested capital at year 15 brought to today, less the net debt today (or plus the net cash).

The projection was not made (an operating profit at or below zero in the latest three years), so the value is the book value today, 440.18M USD, as the screener leaves it.

①Present Value of the 15 Years of FCFF

Not in the value

②Invested Capital at Year 15, Today

Not in the value

③Net Cash Today

Not in the value

Market value

Market Cap7.32B USD

Today's price times the shares.

Value vs market

Margin of Safety-1562.8%

1 minus the market cap as a share of the value.

The Rates and the Capital the Values Read

The WACC and the cost of equity each value is discounted at, the book value and the net debt each starts from, and the seven quality metrics, from the same run.

WACC: 6.45%
weighted average cost of capital: the yearly return the shareholders and the lenders together require, weighted by what each puts in; the rate that brings the firm's future cash to today.
Cost of Equity =Risk-Free Rate 4.50%+Beta 0.42×Market Risk Premium 6.00%= 7.01%

The yearly return the shareholders require for the risk they carry; it is the rate that brings their future cash to today.

Tax Rate for WACC 25.00% (default): the statements print a tax provision of 1.79M USD on a pretax income of -379.98M USD, which gives no rate between 0 and the profit before tax, so the 25% default stands for the tax the interest saves.

Interest Expense =EBIT -295.61M USD−Pretax Income -379.98M USD= 84.37M USD

The interest the company paid: EBIT is the profit before tax plus the interest.

Cost of Debt =Interest Expense 84.37M USDTotal Debt 1.62B USD×(1 − Tax Rate for WACC 25.00%)= 3.92%

What the lenders are paid a year after the tax the interest saves.

Debt Weight =Total Debt 1.62B USDMarket Cap + Total Debt 7.32B USD + 1.62B USD= 18.08%

The part of the capital the lenders put in, at market value.

WACC =Equity Weight 81.92%×Cost of Equity 7.01%+Debt Weight 18.08%×Cost of Debt 3.92%= 6.45%

Weighted average cost of capital: the yearly return the shareholders and the lenders together require, weighted by what each puts in; the rate that brings the firm's future cash to today.

Book value and net debt today
Both from the balance sheet of the newest quarter, 2026-06-30.

Total Assets 3.00B USD − Total Liabilities 2.56B USD = Book Value Today 440.18M USD

Total Debt 1.62B USD − Cash and Short-Term Investments 2.06B USD = Net Debt Today -441.50M USD

The book value is what Profit starts from and what stands when a projection is not made; the book value plus the net debt is what FCFF starts from; the net debt comes off Greenwald's and FCFF's values before the shareholders.

Quality metrics
Read beside the value, never a condition for it: every company is valued, and a filter in the list is the reader's choice.
MetricFrom
Share dilutionShares Today ÷ Shares Two Years Back − 114.9%at most 5%does not pass165,902,064 / 144,340,526
Accrual quality(Operating Cash Flow − Net Income) ÷ Total Assets3.8%at least -10.0%passes(-268.85M USD − -381.77M USD) ÷ 3.00B USD
Price to bookMarket Cap ÷ Book Value Today16.63×at most 3×does not pass7.32B USD ÷ 440.18M USD
Operating marginOperating Income ÷ Revenue-40.4%above 10.0%does not pass-382.10M USD ÷ 944.65M USD
Revenue growthRevenue ÷ Revenue a Year Before − 133.8%above 10.0%passes944.65M USD / 705.84M USD
Net cash(Cash − Total Debt) ÷ Market Cap-17.3%above -30%passes(350.42M USD − 1.62B USD) ÷ 7.32B USD
Operating efficiencyOperating Income ÷ Gross Profit-41.1%above 25.0%does not pass-382.10M USD ÷ 928.73M USD

Market Data

The provider's ratios and the analysts' consensus beside the argument; none of them enters a value.

Market data
The data provider's own ratios and the analysts' consensus, read beside the valuation, never in it.

Share price

44 USD

Enterprise value

7.41B USD

market cap plus net debt

EV / EBITDA

-12.77×

Price / book

16.57×

the provider's book

Price / earnings

—

Return on equity

-105.5%

the provider's, not the engine's

Profit margin

-64.7%

Revenue growth

-40.7%

Analyst target, mean

84 USD

Analysts

22

opinions in the consensus

Financial Statements

The income statement, the balance sheet and the cash flow the screener holds, year by year, in USD.

Financial statements, year by year
The annual lines the screener holds today, in USD at each period's rate; the figures this valuation read are in its calculation above.
USD2022202320242025
Income statement

Revenue

587.95M788.43M705.84M944.65M

Gross profit

573.82M779.29M694.62M928.73M

Operating income

-410.60M-354.08M-475.58M-382.10M

EBITDA

operating income before depreciation and amortisation

-227.99M-230.24M-354.07M-272.90M

Pretax income

-258.24M-334.30M-460.53M-379.98M

Net income

-269.99M-366.65M-454.35M-381.77M

Normalized income

net income without one-off items, as the data provider prints it; Profit's line when printed

-394.46M-431.39M-557.23M-462.22M

R&D

833.98M900.52M902.43M916.53M
Balance sheet, year end

Total assets

2.54B2.99B3.01B3.53B

Total liabilities

1.96B2.61B2.42B3.04B

Shareholders' equity

the equity the parent's shareholders own, as printed, without minority interest; the book value the values read is total assets less total liabilities, in Book Value and Net Debt above

573.46M387.07M588.94M489.58M

Total debt

1.37B1.45B1.42B2.07B

Cash and equivalents

276.75M399.67M242.32M372.63M

Net PP&E

fixed assets after depreciation

256.09M243.18M256.36M361.96M

Working capital

current assets less current liabilities

1.89B2.20B2.31B2.21B
Cash flow

Operating cash flow

-274.64M-307.82M-501.45M-268.85M

Capital expenditure

paid out, so below zero

-20.12M-28.02M-50.39M-57.14M

Depreciation and amortisation

22.13M22.52M22.01M22.72M

Free cash flow

operating cash flow plus capital expenditure

-294.76M-335.84M-551.84M-325.99M